Autoimmune Disease: Easing the Pain with Stem Cells Story by Ivanhoe Broadcast News: DENVER, Colo. (Ivanhoe Newswire) – Fifty million Americans are living with an autoimmune disorder, making it one of the leading causes of chronic illness in the country. In fact, there are more than 80 autoimmune disease. For most, there is no cure. […]
A Manufactured Immune Protein Used to Diagnose and Treat Diseases A monoclonal antibody (mAb) is a type of immune protein produced in a lab that binds to a specific protein on a cell called an antigen. As with naturally occurring antibodies, monoclonal antibodies stimulate the immune system to act against disease-causing agents. Matching a specific […]
Summary The thymus is critical for the establishment of a functional and self-tolerant adaptive immune system but involutes with age, resulting in reduced naive T cell output. Generation of a functional human thymus from human pluripotent stem cells (hPSCs) is an attractive regenerative strategy. Direct differentiation of thymic epithelial progenitors (TEPs) from hPSCs has been demonstrated in vitro, […]
How We Produce Stem Cells… Here is my step-by-step procedural list explaining how we produce stem cells in the laboratory: Source choose suitable source of stem cells: in this case I’ll use“Adult Tissue” generated from adult cells. Cell isolation: For adult tissues isolate the specific cell type you want to reprogram into stem cells. Culturing medium […]
—In vitro and in vivo Sophie Charlotte Rhode, Justus Patrick Beier, Tim Ruhl First published: 18 October 2020 https://doi.org/10.1002/jnr.24738 Abstract After peripheral nerve injury, Schwann cells (SCs) are crucially involved in several steps of the subsequent regenerative processes, such as the Wallerian degeneration. They promote lysis and phagocytosis of myelin, secrete numbers of neurotrophic factors and cytokines, and […]
Summary: Human pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) provide unprecedented opportunities for cell therapies against intractable diseases and injuries. Both ESCs and iPSCs are already being used in clinical trials. However, we continue to encounter practical issues that limit their use, including their inherent properties of […]
Recent advances in understanding the impact of infection and inflammation on hematopoietic stem and progenitor cells Michael D. Milsom a b 1, Marieke A.G. Essers b c 1 https://doi.org/10.1016/j.cdev.2023.203844 Abstract Just over one decade ago, it was discovered that hematopoietic stem cells (HSCs) could directly respond to inflammatory cytokines by mounting a proliferative response thought to mediate the emergency production of mature blood cells. In the […]
Neuropathic pain (NP) is pain caused by somatosensory nervous system injury or disease. Its prominent symptoms are spontaneous pain, hyperalgesia, and allodynia, and the sense of pain is extremely strong. Owing to the complex mechanism, conventional painkillers lack effectiveness. Recently, research on the treatment of NP by stem cells is increasing and promising results have […]
